What are the symptoms and treatment options for neovascularization?

Symptom Database

Neovascularization, also known as angiogenesis, is the formation of new blood vessels in the body. While this process is essential for normal growth and development, it can become problematic when it occurs in an uncontrolled or abnormal manner. One area where neovascularization can cause significant issues is in the eye, leading to conditions such as ocular neovascularization and retinal neovascularization. In this article, we will explore the symptoms and treatment options for neovascularization, including the use of neovascularization inhibitors.

Understanding Neovascularization

Before delving into the symptoms and treatment options, it is important to have a clear understanding of what neovascularization entails. Neovascularization refers to the formation of new blood vessels from pre-existing ones. This process is regulated by various growth factors and cytokines, which stimulate the growth of new blood vessels.

While neovascularization is a normal part of wound healing and tissue repair, it can become pathological in certain conditions. Pathological neovascularization refers to the abnormal growth of blood vessels, which can lead to various complications depending on the affected organ or tissue.

Symptoms of Neovascularization

The symptoms of neovascularization can vary depending on the location and severity of the condition. In ocular neovascularization, which affects the eye, common symptoms include:

  • Blurred or distorted vision
  • Floaters or spots in the visual field
  • Loss of central vision
  • Difficulty seeing in low light conditions
  • Increased sensitivity to glare

These symptoms can significantly impact a person’s quality of life and may require prompt medical attention.

Treatment Options for Neovascularization

Neovascularization Inhibitors

One of the primary treatment options for neovascularization is the use of neovascularization inhibitors. These inhibitors work by targeting the growth factors and cytokines involved in the formation of new blood vessels, thereby preventing their abnormal growth.

Anti-vascular endothelial growth factor (anti-VEGF) drugs are commonly used as neovascularization inhibitors in the treatment of ocular neovascularization and retinal neovascularization. These drugs, such as ranibizumab and bevacizumab, are injected directly into the eye and help to reduce the growth of abnormal blood vessels.

Laser Photocoagulation

Laser photocoagulation is another treatment option for neovascularization, particularly in cases where the abnormal blood vessels are located in the retina. This procedure involves using a laser to seal off the leaking blood vessels and prevent further damage to the retina.


Cryotherapy, which involves freezing the abnormal blood vessels, may also be used in certain cases of neovascularization. This treatment option is particularly effective for retinal neovascularization and can help to reduce the risk of complications such as retinal detachment.

Causes of Neovascularization

Neovascularization can have various underlying causes, and understanding these causes is crucial for effective treatment and prevention. Some common causes of neovascularization include:

  • Chronic inflammation
  • Tumor growth
  • Ischemic conditions
  • Diabetic retinopathy
  • Age-related macular degeneration

Identifying and addressing the underlying cause of neovascularization is essential for successful treatment and management of the condition.

Current Research on Neovascularization

Researchers are continually exploring new avenues for the treatment and prevention of neovascularization. Some areas of current research include:

  • Development of novel neovascularization inhibitors
  • Gene therapy approaches to target abnormal blood vessel growth
  • Identification of biomarkers for early detection and monitoring of neovascularization
  • Investigation of the role of inflammation in neovascularization

These research efforts hold promise for the future management of neovascularization and may lead to more effective treatment options.


Neovascularization is a complex process that can have significant implications for various organs and tissues, particularly in the case of ocular and retinal neovascularization. Understanding the symptoms and treatment options for neovascularization is crucial for early detection and intervention. Neovascularization inhibitors, laser photocoagulation, and cryotherapy are among the treatment options available, depending on the specific case. Ongoing research in the field of neovascularization offers hope for improved management and prevention of this condition in the future.

Haroon Rashid, MD
Rate author
Urgent Care Center of Arlington, VA
Add a comment