What does elevated levels of IgD in the blood indicate and what should I do?

Symptom Database

Elevated levels of IgD in the blood can be a cause for concern, as it may indicate an underlying health issue. IgD, or immunoglobulin D, is a type of antibody that plays a crucial role in the immune system’s defense against infections. While it is normal to have a certain level of IgD in the blood, high IgD levels can be a sign of an immune system dysfunction or an inflammatory condition.

Understanding IgD Blood Levels

IgD is one of the five main types of immunoglobulins, or antibodies, found in the human body. It is primarily produced by B cells, a type of white blood cell, and is involved in the recognition and elimination of pathogens.

Typically, IgD levels in the blood are relatively low compared to other immunoglobulins. However, when there is an immune system response or inflammation, the production of IgD can increase, leading to elevated IgD levels.

Causes of High IgD Levels

There are several potential causes for increased IgD levels in the blood. These include:

  • Autoinflammatory diseases: Conditions such as periodic fever syndromes, including familial Mediterranean fever (FMF) and hyper IgD syndrome (HIDS), can cause recurrent episodes of fever and inflammation, leading to elevated IgD levels.
  • Infections: Certain viral or bacterial infections can trigger an immune response, resulting in increased IgD production.
  • Allergic reactions: In some cases, allergies can cause an elevation in IgD levels.
  • Autoimmune diseases: Conditions like systemic lupus erythematosus (SLE) or rheumatoid arthritis can lead to chronic inflammation and subsequently elevated IgD levels.

What Should I Do if I Have High IgD Levels?

If you have received blood test results indicating elevated IgD levels, it is important to consult with a healthcare professional for further evaluation and diagnosis. They will be able to assess your symptoms, medical history, and conduct additional tests to determine the underlying cause of the high IgD levels.

Depending on the suspected cause, your healthcare provider may recommend the following:

1. Further Testing:

In order to identify the specific condition causing the elevated IgD levels, additional tests may be necessary. These can include genetic testing for autoinflammatory diseases or imaging studies to assess for signs of inflammation or infection.

2. Treatment of Underlying Condition:

If an underlying condition is identified, treatment will be focused on managing and controlling that specific condition. This may involve medications to reduce inflammation, control immune system responses, or treat infections.

3. Lifestyle Modifications:

In some cases, making certain lifestyle changes can help manage symptoms and reduce inflammation. This can include adopting a healthy diet, regular exercise, stress management techniques, and avoiding triggers that may exacerbate symptoms.

4. Regular Follow-up:

It is important to maintain regular follow-up appointments with your healthcare provider to monitor your IgD levels and overall health. This will allow for ongoing assessment of your condition and adjustment of treatment plans as needed.


Elevated IgD levels in the blood can be a sign of an underlying health issue, such as an immune system dysfunction or an inflammatory condition. It is crucial to consult with a healthcare professional if you have high IgD levels to determine the underlying cause and develop an appropriate treatment plan. Regular follow-up and lifestyle modifications may also be necessary to manage symptoms and maintain overall health. Remember, early detection and intervention can lead to better outcomes and improved quality of life.

Haroon Rashid, MD
Rate author
Urgent Care Center of Arlington, VA
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